Direct cellular reprogramming and transdifferentiation of fibroblasts on wound healing—Fantasy or reality?

Global Epigenetic State Network Governs Cellular Pluripotent Reprogramming and Transdifferentiation

Department of Biological Sciences, Virginia Tech, Blacksburg, VA 24060, USA Center for Complex Network Research, Departments of Physics, Biology, and Computer Science, Northeastern University, Boston, MA 02115, USA. Department of Medicine, Harvard Medical School, and Center for Cancer Systems Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA. National Heart, Lung and Blood Institutes...

Cellular Biology MicroRNA-Mediated In Vitro and In Vivo Direct Reprogramming of Cardiac Fibroblasts to Cardiomyocytes

on direct sums of baer modules

the notion of baer modules was defined recently

Direct Reprogramming of Murine Fibroblasts to Hematopoietic Progenitor Cells

Recent reports have shown that somatic cells, under appropriate culture conditions, could be directly reprogrammed to cardiac, hepatic, or neuronal phenotype by lineage-specific transcription factors. In this study, we demonstrate that both embryonic and adult somatic fibroblasts can be efficiently reprogrammed to clonal multilineage hematopoietic progenitors by the ectopic expression of the tr...

Excessive Cellular Proliferation Negatively Impacts Reprogramming Efficiency of Human Fibroblasts.

UNLABELLED The impact of somatic cell proliferation rate on induction of pluripotent stem cells remains controversial. Herein, we report that rapid proliferation of human somatic fibroblasts is detrimental to reprogramming efficiency when reprogrammed using a lentiviral vector expressing OCT4, SOX2, KLF4, and cMYC in insulin-rich defined medium. Human fibroblasts grown in this medium showed hig...